Endocrine complications in survivors of childhood medulloblastoma

Results Thirty-four patients were included in the study. The median age at diagnosis was 7.5 years (range = 0.8 17.2 years) and the median follow-up time was 10.45 years (range = 2 – 18.3 years). Hypothyroidism was diagnosed in 16 patients (Primary hypothyroidism = 5 patients; compensated hypothyroidism = 10 patients; central hypothyroidism = 1 patients) and it was the commonest endocrine complication among this group of patients. The median time to develop hypothyroidism was 50 months (range = 15-155 months) from diagnosis. Male sex was the only risk factor that was found to be associated with the development of hypothyroidism (OR= 3.14; p = 0.031). Eight patients developed growth hormone deficiency and eight patients developed gonadal dysfunction. Age at diagnosis, dose and fractions of radiotherapy, chemotherapy regimen and duration of follow-up were all not associated with the development of these complications.